Gambling et al FETAL IRON STATUS REGULATES MATERNAL IRON METABOLISM DURING PREGNANCY IN THE RAT
نویسندگان
چکیده
Rowett Institute of Nutrition and Health, University of Aberdeen, Greenburn Road, Bucksburn Aberdeen AB21 9SB, UK Biomathematics and Statistics Scotland, Rowett Institute of Nutrition and Health, Greenburn Road, Aberdeen AB21 9SB, UK Dept of Biochemistry and Molecular Biology, Royal Free Hospital, Rowland Hill Road, London NW3 2QG, UK Department of Hygiene and Human Nutrition, Agricultural University, Wojska Polskiego 31, 60-624 Poznan, Poland
منابع مشابه
Fetal iron status regulates maternal iron metabolism during pregnancy in the rat.
Iron metabolism during pregnancy is biased toward maintaining the fetal supply, even at the cost of anemia in the mother. The mechanisms regulating this are not well understood. Here, we examine iron deficiency and supplementation on the hierarchy of iron supply and the gene expression of proteins that regulate iron metabolism in the rat. Dams were fed iron-deficient diets for 4 wk, mated, and ...
متن کاملThe effect of feeding a low iron diet prior to and during gestation on fetal and maternal iron homeostasis in two strains of rat
BACKGROUND Iron deficiency anaemia during pregnancy is a global problem, with short and long term consequences for maternal and child health. Animal models have demonstrated that the developing fetus is vulnerable to maternal iron restriction, impacting on postnatal metabolic and blood pressure regulation. Whilst long-term outcomes are similar across different models, the commonality in mechani...
متن کاملEffect of dietary copper deficiency on iron metabolism in the pregnant rat.
Cu and Fe metabolism are known to be linked, but the interactions during pregnancy are less well studied. In the present study we used rats to examine the effect of Cu deficiency during pregnancy on Fe and Cu levels in maternal and fetal tissue and on the gene expression profile of proteins involved in Cu and Fe metabolism in the placenta. Rats were fed diets with different Cu contents before a...
متن کاملMaternal iron status influences iron transfer to the fetus during the third trimester of pregnancy.
BACKGROUND The effect of maternal iron status on fetal iron deposition is uncertain. OBJECTIVE We used a unique stable-isotope technique to assess iron transfer to the fetus in relation to maternal iron status. DESIGN The study group comprised 41 Peruvian women. Of these women, 26 received daily prenatal supplements containing iron and folate (n = 11; Fe group) or iron, folate, and zinc (n ...
متن کاملThe effect of iron deficiency on the temporal changes in the expression of genes associated with fat metabolism in the pregnant rat
Iron is essential for the oxidative metabolism of lipids. Lipid metabolism changes during gestation to meet the requirements of the growing fetus and to prepare for lactation. The temporal effects of iron deficiency during gestation were studied in female rats fed complete or iron-deficient diets. Plasma triglycerides were elevated in the iron-deficient group throughout gestation. There were ti...
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تاریخ انتشار 2009